擅長： 醫學影像診斷和分子影像學研究

簡介： 現任中山大學附屬腫瘤醫院影像與微創介入中心教授/主任醫師，博士生導師。華南腫瘤學國家重點實驗室(2004DA105074)課題組負責人。廣東省高等學校“千百十工程”第七批省級培養對象。 專業學會兼職： 中國生物物理學會分子影像學專業委員會第一屆委員 中國抗癌協會大腸癌專業委員會肝轉移學組第一屆委員 廣東省抗癌協會大腸癌專業委員會常務委員 廣東省放射學會心胸學組委員 臨床醫療與科學研究經驗： 李立教授長期從事醫學影像診斷和分子影像學研究工作，在智能磁共振造影劑研制、新型納米探針研發、腫瘤分子分期、多模態分子成像理論與動物模型研究取得了重要成果。發表通訊作者/第一作者SCI收錄論著24篇，其中，通訊作者(或共同通訊作者)論著發表在Scientific Reports, Biomaterials, Clinical Cancer Research, Nanoscale, Cancer, Contrast Media & Molecular Imaging等國際著名期刊。以第一發明人獲得新型釓納米造影劑、乳腺影像CAD系統、穩定表達Tet-off Advanced鼻咽癌細胞模型發明專利3項，申報多模態分子成像探針發明專利1項。 科研基金： 1、國家自然科學基金面上項目，81271622、釓-納米金雙模態分子成像探針及其成像相互影響機制的研究、2013/01-2016/12、85萬元、主持。 2、國家自然科學基金面上項目，81071207、鼻咽癌生物發光與磁共振多模態成像模型研究、2011/01-2013/12、35萬元、主持。 3、廣州市科技支撐計劃項目，2010J-E151、東方女性適用的乳腺鉬靶攝影計算機輔助診斷系統、2011/01-2013/12、15萬元、主持。 4、高校基本科研業務費中山大學重大項目培育和新興交叉學科資助計劃項目、10ykjcll、腫瘤分子影像基礎研究、2010/07-2012/12、30萬元、主持。 5、國家自然科學基金面上項目，30770629、含釓納米材料磁共振分子影像造影劑的研制、2008/01-2010/12、28萬元、主持。 6、廣州市科技計劃項目，2006Z3-D2041、新型磁共振造影劑—釓摻雜復合納米材料的研制、2006/01-2008/12、30萬元、主持。 近年來發表論著(*通訊作者)： 1. Cao CY, Shen YY, Wang JD, Li L*, Liang GL*. Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents. Sci Rep 2013,3,1024 doi:10.1038/srep01024 (2013). 2. Tian XM, Shao YZ, He HQ, Liu H, Shen YY, Huang WL*, Li L*. Nanoamplifiers synthesized from gadolinium and gold nanocomposites for magnetic resonance imaging. Nanoscale 2013, 5(8), 3322-3329 3. Shen Y, Shao Y, He H, Tan Y, Tian X, Xie F*, Li L*. Gadolinium(3+)-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo. Int J Nanomedicine 2013,8:119-127 4. Cai HM, Cui CY, Tian HY, Zhang M, Li L*. A novel approach to segment and classify regional lymph nodes on computed tomography images. Comput Math Method M 2012,2012:145926 doi:10.1155/2012/ 145926 5. Shao YZ, Tian XM, Hu WY, Zhang YY, Liu H, He HQ, Shen YY, Xie FK, Li L*. The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI. Biomaterials 2012,33(27):6438-6446 6. Feng YP, Liu QC, Zhu JF, Xie FK, Li L*. Efficiency of ferritin as an MRI reporter gene in NPC cells is enhanced by iron supplementation. J Biomed Biotechnol 2012,2012:434878 doi:10.1155/2012/434878 7. Pang YC#, Li L#, Hu WY, Peng YX, Liu LZ, Shao YZ*. Computerized segmentation and characterization of breast lesions in dynamic contrast-enhanced MR images using Fuzzy c-means clustering and snake algorithm. Comput Math Method M 2012,2012:634907 doi:10.1155/2012/634907 (2011 SCI IF 0.684) 8. Cui CY, Cai HM, Liu LZ, Li LR, Tian HY, Li L*. Quantitative analysis and prediction of regional lymph node Status in rectal cancer based on computed tomography imaging. Eur Radiol 2011,21(11):2318-2325 9. Shao YZ, Liu LZ, Song XQ, Cao RH, Liu H, Cui CY, Li X, Bie MJ, Li L*. A novel one-step synthesis of Gd3+ incorporated mesoporous SiO2 nanoparticles for use as an efficient MRI contrast agent. Contrast Media Mol Imaging 2011,6(2):110-118 10. Feng YP, Liu QC, Zhu JF, Xie FK, Li L*. Development and applications of a nasopharyngeal carcinoma Tet-Off cell line. Oncol Lett 2011, 3(2):525-530 11. Shao YZ, Liu LZ, MJ, Li CC, Wu YP, Xie XM, Li L*. Characterizing the clustered microcalcifications on mammograms to predict the pathological classification and grading: a mathematical modeling approach. J Digital Imaging 2011, 24(5):764-771 12. Liu LZ, Liang SB, Li L*, Mao YP, Tang LL, Tian L, Liao XB, Cui CY, Lin AH, Ma J*. Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma. Cancer 2009,115(9):1995-2003 13. Cui CY, Liu LZ, Ma J, Liang SB, Tian L, Tang LL, Li L*. Trigeminal nerve palsy in nasopharyngeal carcinoma: Correlation between clinical findings and magnetic resonance imaging. Head Neck 2009,31(6):822-828 14. Li L, Liu LZ, Wu QL, Mo YX, Liu XW, Cui CY, Wan DS*. CT-guided core needle in diagnosis of pancreatic diseases with an automated biopsy gun. J Vasc Interv Radiol 2008,19(1):89-94 15. Ma J, Liu L, Tang L, Zong J, Lin A, Lu T, Cui N, Cui C, Li L*. Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: prognostic value and staging categories. Clin Cancer Res 2007,13(5):1445-1452 16. Liu LZ, Zhang GY, Xie CM, Liu XW, Cui CY, Li L*. Magnetic resonance imaging of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: patterns of spread. Int J Radiat Oncol Biol Phys 2006,66(3):721-730 17. Li L, Wu PH, Huang JL, Liu RY, Zeng YX, Huang WL*. Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma. Int J Cancer 2006,118(8):2064-2071